Recombinant human bone morphogenetic protein-2 (rhBMP-2) for cervical fusion: Is there a role in cervical trauma?

Abstract

Objective: To identify a high quality bone source for cervical fusion especially in the setting of trauma, while avoiding the morbidity of iliac crest grafting and the issues of non healing or resorbtion with homologous or allo or xenografts. Method: Using poly-ether-ether-ketone (PEEK) cages as containers, rhBMP-2 was placed in an absorbable collagen sponge as the sole bone source in 3 patients who underwent a 2 level anterior cervical fusion and rigid plating. Results: Cervical fusion at both levels of the cervical spine was obtained in the 3 patients starting at 8 weeks postoperatively and was solid at 4-6 months after surgery without any complications. Conclusion: rhBMP-2 contained in an absorbable collagen sponge is an excellent osteoinductor for cervical fusion, free of adverse effects, avoiding the need for autologous bone grafts. Additional evaluations are necessary to determine the long-term efficacy of rhBMP-2. The use of rhBMP-2 within a synthetic or allograft bone source may obviate the need for autologous bone graft harvesting in the setting of cervical trauma. © 2006 Thomas Land Publishers, Inc.