Abstract
Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P
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Anderson, A. W., Heptulla, R. A., Driesen, N., Flanagan, D., Goldberg, P. A., Jones, T. W., … Gore, J. C. (2006). Effects of hypoglycemia on human brain activation measured with fMRI. Magnetic Resonance Imaging, 24(6), 693–697. https://doi.org/10.1016/j.mri.2006.03.013
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