Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development

43Citations
Citations of this article
47Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The growth factor family of neurotrophins has major roles both inside and outside the nervous system. Here, we report a detailed histological analysis of key phenotypes generated by the ablation of the Kinase D interacting substrate of 220 kDa/Ankyrin repeat-rich membrane spanning (Kidins220/ARMS) protein, a membrane-anchored scaffold for the neurotrophin receptors Trk and p75 NTR. Kidins220 is important for heart development, as shown by the severe defects in the outflow tract and ventricle wall formation displayed by the Kidins220 mutant mice. Kidins220 is also important for peripheral nervous system development, as the loss of Kidins220 in vivo caused extensive apoptosis of DRGs and other sensory ganglia. Moreover, the neuronal-specific deletion of this protein leads to early postnatal death, showing that Kidins220 also has a critical function in the postnatal brain. © 2011 Macmillan Publishers Limited All rights reserved.

Cite

CITATION STYLE

APA

Cesca, F., Yabe, A., Spencer-Dene, B., Arrigoni, A., Al-Qatari, M., Henderson, D., … Schiavo, G. (2011). Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development. Cell Death and Disease, 2(11). https://doi.org/10.1038/cddis.2011.108

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free