Tratamento de macroprolactinoma com cabergolina em adolescente

Abstract

Objective: To report a teenager with macroprolactinoma treated with cabergoline. Case description: A 15-year old female adolescent reported the onset of headaches and obesity since ten years old. At diagnosis amenorrhea was not present. The serum level of prolactin was initially 2492ng/mL (reference values: 19-25ng/mL). Magnetic resonance images of the skull revealed an expansive sellar and suprasellar pituitary macroadenoma without optical chiasmal compression. Six months after starting treatment with cabergoline, there was a signifcant decrease of prolactin levels to 87.7 ng/mL, with a 76% reduction in the lesion size and she reported improvement of the symptoms. Comments: In childhood and adolescence, prolactinomas are rare, but when they occur the clinical course is more aggressive. Early diagnosis and proper management of the disease are important for a good prognosis.