Abstract
A series of Novel Mannich bases has been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1), and human breast cancer (MCF-7). Compound 9f was found to be most potent against three cell lines with IC50 values of 1.57, 1.16 and 1.21 μg/mL, respectively. In addition, compounds 9g, 10f exhibited very significant activity against MCF-7 cell line with IC50 values of 2.0 μg/mL. © 2005 KCSNET.
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Hieu, B. T., Thuy, L. T., Thuy, V. T., Tien, H. X., Chinh, L. V., Hoang, V. D., & Vu, T. K. (2012). Design, synthesis and In Vitro cytotoxic activity evaluation of new mannich bases. Bulletin of the Korean Chemical Society, 33(5), 1586–1592. https://doi.org/10.5012/bkcs.2012.33.5.1586
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