Neural processing associated with true and false memory retrieval

Abstract

We investigated the neural bases for false memory with fMRI by examining neural activity during retrieval processes that yielded true or false memories. We used a reality monitoring paradigm in which participants saw or imagined pictures of concrete objects. (A subsequent misinformation task was also used to increase false memory rates.) At test, fMRI data were collected as the participants determined whether they had seen or had only imagined the object at study. True memories were of seen pictures accurately endorsed as seen, and for false memories were of imagined pictures falsely endorsed as seen. Three distinct patterns of activity were observed: Left frontal and parietal activity was not different for true and for false memories, whereas activity was greater for true than for false memories in occipital visual regions and posterior portions of the parahippocampal gyrus, and activity was greater for false than for true memories in right anterior cingulate gyrus. Possible interpretations are discussed.