Norovirus GII.4 Virus-like particles recognize galactosylceramides in domains of planar supported lipid bilayers

Abstract

A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.