Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway

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Abstract

Background: The proteolytic regulation of DNA repair factors remains poorly understood. Results: Six proteins involved in nucleotide excision repair are found to be degraded by the proteasome. Conclusion: Rad25 is selected for proteasomal degradation by the Ubc4-Ufd4 pathway. Significance: Our results provide novel insights into the role of the proteasome in DNA repair.

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Bao, X., Johnson, J. L., & Rao, H. (2015). Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway. Journal of Biological Chemistry, 290(13), 8606–8612. https://doi.org/10.1074/jbc.M114.618793

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