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SIR2-induced inviability is suppressed by histone H4 overexpression

Genetics (2002) 162(2) 973-976
DOI: 10.1093/genetics/162.2.973
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Abstract

We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specific interaction between Sir2 and H4 in the silencing mechanism.

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Matecic, M., Stuart, S., & Holmes, S. G. (2002). SIR2-induced inviability is suppressed by histone H4 overexpression. Genetics, 162(2), 973–976. https://doi.org/10.1093/genetics/162.2.973

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