A revised model for spermatological expansion in man: Lessons from non-human primates

Abstract

We have recently described a revised scheme for spermatogonial expansion in non-human primates. We proposed that Apale-spermatogonia act as self-renewing progenitors and premeiotic germ cells are organized and divide as small clones. Here, we are revisiting the model described for man and propose a modified scheme for spermatogonial expansion. Our revised model shows high similarity to the scheme proposed for non-human primates and is in accordance with all previous and present data. © 2006 Society for Reproduction and Fertility.