Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation

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Abstract

S-Fluoroacetylation of cysteine residues enables efficient cleavage of main-chain amide bonds in peptides and proteins under neutral aqueous conditions.

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Matsumoto, Y., Zenmyo, N., Watanabe, S., Sasaki-Tabata, K., Uchinomiya, S., Shindo, N., & Ojida, A. (2025). Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation. Chemical Communications, 61(62), 11625–11628. https://doi.org/10.1039/d5cc02215k

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