Type 1 diabetes mellitus, diabetic nephropathy: Transplantology potential

Abstract

The review covers the role of transplantology in treatment of patients with type 1 diabetes and the state of its development in the world and in Russia. The results of major multicenter studies, devoted to the influence of simultaneous kidney and pancreas transplantation and kidney transplantation alone on life expectancy and quality of life of diabetic patients are summarized here. Experience in pancreas-kidney transplantation, gained in Academician V.I. Shumakov Federal ResearchCenterof Transplantology and ArtificialOrgans, isdescribed, includingsurgical technical and postoperative treatment. Also we peiform the results of research work, devoted to of pancreas transplantation on different homeostasis parameters, such as: oxidative stress parameters, homocysteine, receptor for advanced glycation endproduct (RAGE), and markers of endocrine function of pancreas transplant.