3D Ultrasound Navigation System with Reconstruction of Blood Vessel Network for Microbubble Delivery Therapy

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 263810628 3D Reconstruction Microbubble . . . Article DOI : 10 . 14326 / abe . 3 . 29 CITATION 1 READS 109 7 , including : Shinya Kyushu 61 SEE Antoine Kanagawa 81 SEE Ren Gunma , Kiryu , Japan 36 SEE Kohji Tokyo 145 SEE All . The . All - text and , letting . Abstract This paper provides a 3D ultrasound navigation system with a blood vessel network (BVN) reconstruction algorithm for microbubble delivery therapy , which manipulates microbubbles in blood vessel by acoustic radiation force of ultrasound , aiming to increase the efficiency of high - intensity focused ultrasound (HIFU) and realize acoustic drug / gene delivery . To apply the technique in vivo , reconstruction of the BVN from 3D volume , such as bifurcation positions and flow direction , and visualization of the relative positions of the BVN and ultrasound field for microbubble manipulation are required . To address these issues , we have developed a 3D ultrasound navigation system to guide microbubbles in blood vessel . The novel navigation system consists of an ultrasound imaging device with a 2D array probe , an optical tracking device , a focused ultrasound transducer , and a Windows workstation with in - house navigation software . The system visualizes three - dimensionally both the BVN and the focal position of the transducer . When a 3D volume is acquired by an imaging device , the volume is automatically sent to the navigation system . Then , the system visualizes the volume and its bifurcations , which are estimated by 3D thinning processing . In this study , we examined the feasibility of the system by evaluating the guidance accuracy and microbubble induction rate . From the results , we confirm that microbubbles can be navigated by the system .