Adaptive designs for clinical trial

Abstract

OBJECTIVE: In order to provide readers with general concepts and methodology on adaptive designs for clinical trial. METHODS: Definition of adaptive designs for clinical trial and basic idea of adaptive adjustment were introduced through an example. RESULTS: The relationship between adaptive designs and group sequential design was summarized. Ways to embody two basic statistical rules of clinical trial under adaptive adjustments setting were also introduced. CONCLUSION: Adaptive designs provided clinical trial with a great flexibility, which could greatly improve the efficiency of clinical trial.