Machine learning for medical imaging-based COVID-19 detection and diagnosis

Abstract

The novel coronavirus disease 2019 (COVID-19) is considered to be a significant health challenge worldwide because of its rapid human-to-human transmission, leading to a rise in the number of infected people and deaths. The detection of COVID-19 at the earliest stage is therefore of paramount importance for controlling the pandemic spread and reducing the mortality rate. The real-time reverse transcription-polymerase chain reaction, the primary method of diagnosis for coronavirus infection, has a relatively high false negative rate while detecting early stage disease. Meanwhile, the manifestations of COVID-19, as seen through medical imaging methods such as computed tomography (CT), radiograph (X-ray), and ultrasound imaging, show individual characteristics that differ from those of healthy cases or other types of pneumonia. Machine learning (ML) applications for COVID-19 diagnosis, detection, and the assessment of disease severity based on medical imaging have gained considerable attention. Herein, we review the recent progress of ML in COVID-19 detection with a particular focus on ML models using CT and X-ray images published in high-ranking journals, including a discussion of the predominant features of medical imaging in patients with COVID-19. Deep Learning algorithms, particularly convolutional neural networks, have been utilized widely for image segmentation and classification to identify patients with COVID-19 and many ML modules have achieved remarkable predictive results using datasets with limited sample sizes.