2D J-resolved spiral spectroscopic imaging at 7 T: Application to mobile lipid mapping in a rat glioma

Abstract

Lactate (Lac) and mobile lipids (Lip), which are present in rat gliomas, are difficult to map because their 1H resonances overlap in the 1.3 ppm region. 2D J-resolved spectroscopy enables proper separation of the two resonance lines. To obtain high-spatial-resolution mapping of Lac and Lip resonances within a reasonable experiment time, we coupled 2D J-resolved spectroscopy with a fast spectroscopic imaging (SI) method, based on an-out-and-in spiral k-space description. The method was applied to a rat glioma at 7 T, and Lac and Lip maps were reconstructed. The duration of SI (2D spatial, 2D spectral) was 64 min for a theoretical in-plane resolution of 1 × 1 mm, and a slice thickness of 2 mm (voxel size 8.2 μl, taking into account the point-spread function (PSF)). © 2004 Wiley-Liss, Inc.