Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle

Abstract

Background: Dysregulation of Ca2+ homeostasis have been described in malignant hyperthermia (MH). Results: Na+/Ca 2+ exchanger (NCX3) reverse mode activity is enhanced in MH muscles and it contributes to resting intracellular calcium concentration and Ca 2+ transients induced by high [K+]e and by halothane. Conclusion: NCX3 reverse mode activity is increased in MH muscle. Significance: Understanding mechanisms influencing Ca2+ dynamics in MH muscle. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.