Vilsmeier‐Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis‐pyrazole derivatives containing a hydro‐phosphoryl unit. Bis‐{4‐formyl‐3‐aryl‐1H‐pyrazol‐1‐yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4‐phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis‐pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.
CITATION STYLE
Abdel-Aziz, S. A.-G., Ali, T. E.-S., El-Mahdy, K. M., & Abdel-Karim, S. M. (2011). Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit. European Journal of Chemistry, 2(1), 25–35. https://doi.org/10.5155/eurjchem.2.1.25-35.208
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