Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit

  • Abdel-Aziz S
  • Ali T
  • El-Mahdy K
  • et al.
N/ACitations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

Vilsmeier‐Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis‐pyrazole derivatives containing a hydro‐phosphoryl unit. Bis‐{4‐formyl‐3‐aryl‐1H‐pyrazol‐1‐yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4‐phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis‐pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.

Cite

CITATION STYLE

APA

Abdel-Aziz, S. A.-G., Ali, T. E.-S., El-Mahdy, K. M., & Abdel-Karim, S. M. (2011). Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit. European Journal of Chemistry, 2(1), 25–35. https://doi.org/10.5155/eurjchem.2.1.25-35.208

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free