Isoprinosine Induces a Rapid Lympho-Mononuclear Response in Adult Participants

Abstract

Isoprinosine™ is a drug with immunomodulatory and antiviral properties. It exerted beneficial clinical effect in patients with HSV, HZV, HPV, HBV, influenza and subacute sclerosing panencephalitis. We established an elevation of PBMC and absolute number of small and large lymphocytes in adult participants prior and after a single-day intake of Isoprinosine™. The study design permits to observe the mononuclear circadian fluctuation and helps to eliminate the natural diurnal variation when evaluating Isoprinosine™ induced enhancement of PBMC. An increased number of lymphocytes in the afternoon were more expressed after Isoprinosine™ intake and rapid IsoprinosineTM response was observed in ¾ of the participants. This is consistent with previous observations for rapid resolution of the common cold at the first day after initiation of Isopriosine™ therapy. This study provides a model to evaluate the potential immunomodulatory effect of other drugs.