Histopatological Description Of Liver And Kidney Of Mice Exposed To The Ethanol Extract Of Syzygium Myrtifoliumwalp Leaves

Abstract

Purpose: Aimed toasses the toxic effects of ethanol extract of red shoot leaves to the histopathological picture of liver and kidneys of mice (Mus musculus). Design / methodology / approach: The treatment groups consisted of 5 groups which were divided into; negative control groups (Na-CMC), P1 (500 mg / KgBW), P2 (1000 mg / KgBW), P3 (2000 mg / KgBW) and P4 (4000 mg / KgBW). Findings: The result of histological observation showed that the exposed of variation dose of red shoot leaves extract from 500 to 4000 mg / KgBB caused any changes in liver and kidney cells. They were congestion, sinusoid dilation, mononuclear cell infiltration, and inflammation in the liver. The kidney showed appearance of necrotic cells in the proximal tubule, the infiltration of inflammatory cells, and mononuclear. Research limitations / implications: Practical implications: Originality / value: The toxic effect of ethanol extract of Syzygium myrtifoliumWalp. Leavesto liver and kidney in mice. Paper type: Research paper