TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells

Abstract

Background: Although tripartite motif-containing protein 11 (TRIM11) is known to be associated with a variety of cancers, its role in nasopharyngeal carcinoma (NPC) is unclear. Methods and results: To investigate the role of TRIM11 in NPC, TRIM11 was stably overexpressed in 6–10B and CNE2 cells with lentiviral vectors and knocked down in S18 and 5–8F cells using the CRISPR/Cas9 system. Transwell assays and wound-healing assays revealed that TRIM11 facilitated the migration and invasion of NPC cells. Mechanistically, we found that p53 inhibits TRIM11 expression by binding to its promoter. Conclusions: TRIM11 may serve as a potential diagnostic marker for NPC and has a certain therapeutic value.