Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method

Abstract

The main objective of the current study was to enhance the solubility and dissolution of poorly water soluble drug Loratadine (LOR) through formulation of solid dispersion systems (SDs) using hydrophilic polymers. SDs were prepared by kneading method using different drug-to-polymer ratios (1:3 and 1:5) with poloxomer 188 (samples DS1, DS2) and poloxomer 407 (samples DS3, DS4) as hydrophilic polymers. In vitro drug release studies were performed on prepared SDs (DS1-DS4) and compared to pure drug (LOR only, sample DS0). Prepared SDs showed significant improvement in the release profile compared to LOR.