Pleiotropic effects of statins

Abstract

Systematization of pleiotropic actions of statins is presented with special stress on effects important for prevention of atherosclerotic diseases, nonatherosclerotic cardiovascular diseases, and diseases of noncardiovascular origin. Dependence of pleiotropic effects of statins on dose and duration of administration is shown. The review contains data on novel studies of pleiotropic effects favorably affecting endothelial function, oxidative stress, arterial pressure, angiogenesis, heart failure, and disturbances of cardiac rhythm.