Reaction of 5-Amino-1-aryl-3-methylpyrazoles with benzylidene derivatives of meldrum's acid: Synthesis and characterization of pyrazolo[3,4-b]pyridinones

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Abstract

A series of dihydropyrazolo[3,4-b]pyridin-6-ones 3 was prepared by cyclization of 5-amino-1-aryl-3-emthylpyrazoles 1 and Meldrum's acid benzylidene derivatives 2 in nitrobenzene. The structure of 4,5- dihydropyrazolo[3,4-b]pyridin-6-ones and reaction orientation were determined by nmr measurement.

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Quiroga, J., Hormaza, A., Insuasty, B., & Márquez, M. (1998). Reaction of 5-Amino-1-aryl-3-methylpyrazoles with benzylidene derivatives of meldrum’s acid: Synthesis and characterization of pyrazolo[3,4-b]pyridinones. Journal of Heterocyclic Chemistry, 35(2), 409–412. https://doi.org/10.1002/jhet.5570350225

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