Super-Soft DNA/Dopamine-Grafted-Dextran Hydrogel as Dynamic Wire for Electric Circuits Switched by a Microbial Metabolism Process

Abstract

Engineering dynamic systems or materials to respond to biological process is one of the major tasks in synthetic biology and will enable wide promising applications, such as robotics and smart medicine. Herein, a super-soft and dynamic DNA/dopamine-grafted-dextran hydrogel, which shows super-fast volume-responsiveness with high sensitivity upon solvents with different polarities and enables creation of electric circuits in response to microbial metabolism is reported. Synergic permanent and dynamic double networks are integrated in this hydrogel. A serials of dynamic hydrogel-based electric circuits are fabricated: 1) triggered by using water as switch, 2) triggered by using water and petroleum ether as switch pair, 3) a self-healing electric circuit; 4) remarkably, a microbial metabolism process which produces ethanol triggering electric circuit is achieved successfully. It is envisioned that the work provides a new strategy for the construction of dynamic materials, particularly DNA-based biomaterials; and the electric circuits will be highly promising in applications, such as soft robotics and intelligent systems.