Abstract
Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1-4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity.
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Sun, Y. J., Gao, M. L., Zhang, Y. L., Wang, J. M., Wu, Y., Wang, Y., & Liu, T. (2016). Labdane diterpenes from the fruits of sinopodophyllum emodi. Molecules, 21(4). https://doi.org/10.3390/molecules21040434
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