Reduced childhood mortality after standard measles vaccination at 4-8 months compared with 9-11 months of age

Abstract

Objective - To evaluate the impact on mortality of standard Schwarz measles immunisation before 9 months of age. Design - Children vaccinated in 1980-3 at 4-5, 6-8, and 9-11 months of age were followed to migration, death, or the age of 5 years. Setting - One urban district and nine villages in two rural areas of Guinea-Bissau. Subjects - 307 children vaccinated at 4-8 months and 256 at 9-11 months. Main outcome measures - Mortality from 9 months to 5 years of age for children immunised at 4-5, 6-8, and 9-11 months. Results - Mortality was significantly lower in children vaccinated at 6-8 months than at 9-11 months (mortality ratio=0·63, (95% confidence interval 0·41 to 0·97), p=0·047). As vaccination was provided in semiannual or annual campaigns it is unlikely that age at vaccination reflected a selection bias. The trend was the same in all three study areas. Improved survival after early immunisation was not related to better protection against measles infection. With a Cox multivariate regression model to adjust for age, sex, season at risk, season at birth, measles infection, and region, children vaccinated at 4-8 months had a mortality ratio of 0·61 (0·40 to 0·92, p=0·020) compared with children vaccinated at 9-11 months. Reimmunised children tended to have lower mortality than children who received only one vaccine (0·59 (0·28 to 1·27, p=0·176)). Conclusion - Standard measles vaccination before 9 months is not associated with higher childhood mortality than is the currently recommended strategy of immunising from 9 months, and it may reduce mortality. This has implications for measles immunisation strategy in developing countries.