Effect of ionic crosslinking on morphology and thermostability of biomimetic supercritical fluids-decellularized dermal-based composite bioscaffolds for bioprinting applications

Abstract

In the present study, supercritical fluid was employed to prepare a kind of supercritical fluids-decellularized dermal-based scaffold (SFDDS) from porcine dermal tissue. Further, new composite bioscaffolds containing SFDDS were designed for bioprinting applications. Then, the effect of crosslinking functionality on microstructures and thermal properties of the composite bioscaffolds containing decellularized extracellular matrix were studied. The results of thermal stability from thermogravimetric analysis and difference thermogravimetry demonstrated the structural stability of the composite bioscaffolds. A method was designed to prepare bioinspired decellularized dermal-based composite bioscaffolds, which were further characterized by infrared spectroscopy, scanning electron microscopy, and thermogravimetry analysis.