Protein β-interfaces as a generic source of native peptide tectons

Abstract

Motifs of 7–8 amino acids were designed from the α-continuous interfaces of non-related homo-oligomeric proteins. These peptides intrinsically self-assembled into nanoarchitectures in water, while retaining some properties of their parent interfaces, especially reversibility of assembly. These results reveal a novel source of native peptide tectons. © 2013 The Royal Society of Chemistry.