Ablation of klotho and premature aging: Is 1,25-dihydroxyvitamin D the key middleman

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Abstract

The reversal of soft-tissue abnormalities and prolonged lifespan observed in klotho-/- mice following genetic inactivation of 1α-hydroxylase underscores the pathophysiological role of 1,25-dihydroxyvitamin D in mediating some of the premature aging-like features observed in klotho/- mice. © 2009 International Society of Nephrology.

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Wong, Y. F., & Xu, Q. (2009). Ablation of klotho and premature aging: Is 1,25-dihydroxyvitamin D the key middleman. Kidney International. Nature Publishing Group. https://doi.org/10.1038/ki.2009.55

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