Effect of Neonatal Hyperbilirubinemia on Ventricular Functions

Abstract

Objectives: Unconjugated hyperbilirubinemia is a common systemic disease in neonates. Many studies on etiology, risk factors, and treatment have been conducted, and guidelines have been established. Because unconjugated hyperbilirubinemia is a systemic disease, it affects the body, cells, cellular organelles, organs, and systems. Studies have also attempted to clarify the levels, mechanisms, and organs affected by unconjugated bilirubin. We aimed to investigate the effect of high unconjugated bilirubin levels on the left and right ventricular systolic and diastolic functions in newborns by echocardiography and Doppler. Materials and Methods: This observational retrospective cohort study evaluated neonates with hyperbilirubinemia requiring treatment according to the American Academy of Pediatrics guidelines, who were admitted to our unit between January 2017 and December 2017. Results: There was no correlation between the serum total bilirubin levels and the echocardiographic measures. Conclusions: In our study, unconjugated hyperbilirubinemia did not affect the left and right ventricular functions.