The Regulation of Telomerase by Alternative Splicing of TERT

Abstract

Telomeric DNA consists of tandem oligonucleotide repeats that serve to protect ends of linear eukaryotic chromosomes against chromosome end-to-end fusion. The sequence of the repeat differs among distinct groups of eukaryotes and, with the exception of several Fungi species, is usually 5 to 8 nucleotides-long (Gomes et al., 2010; Watson {&} Riha, 2010). Since DNA polymerase cannot replicate the ends of linear chromosomes, chromosomal ...