Lanthanide nitrates as lewis acids in the one-pot synthesis of 1,2,4-oxadiazole derivatives

Abstract

In this work we report the use of lanthanide nitrates [Ln(NO 3)3] acting as catalyst in direct one-pot synthesis of 3-benzoyl- and 3-acetyl-1,2,4-oxadiazoles derivatives from ketones, nitriles and nitric acid. This is the first example of one-pot synthesis of benzoyl- and acetyl 1,2,4-oxadiazoles derivatives preparation using acetophenones derivates with electron-donator groups. © 2012 Sociedade Brasileira de Química.