Rare genetic causes of lissencephaly may implicate microtubule-based transport in the pathogenesis of cortical dysplasias

Abstract

The causative genes for lissencephaly-including LIS1, DCX, and TUBA1A-highlight the importance of a microtubule-based transport pathway in cortical development and potentially in pathogenesis of focal cortical dysplasias. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.