PREPARATION AND EVALUATION OF INTRAORAL DRUG DELIVERY SYSTEM FOR RASAGILINE MESYLATE

Abstract

The aim of the present work was to prepare and evaluate a buccal film for intraoral delivery of Rasagiline. Formulations were prepared using 32 full factorial design to explore the effects of carbopol P 940 and sodium alginate (as independent variables) on mucoadhesive strength and drug release (as dependent variables). In addition to the above, the prepared films were also evaluated for surface pH, percentage moisture absorption (PMA), Percentage moisture loss (PML), folding endurance and content uniformity. The release profile data was subjected to curve fitting analysis to describe the release mechanism from the buccal films. The main effects and the interaction terms were quantitatively evaluated by quadratic model. The Rasagiline release was decreased with increase in both the polymers. Carbopol has more pronounced effect than sodium alginate on the mucoadhesive strength. The objective of the study is to optimize formulation with desirable mucoadhesive strength and drug release. The experimented values are in good agreement with expected values for the optimized formulation which demonstrate the feasibility of the model in the development of buccal film.