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The double life of RIPK1

Molecular and Cellular Oncology (2016) 3(1)
DOI: 10.1080/23723556.2015.1035690
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Abstract

We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine tumor necrosis factor.

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Jin, L., Chen, J., Liu, X. Y., Jiang, C. C., & Zhang, X. D. (2016). The double life of RIPK1. Molecular and Cellular Oncology, 3(1). https://doi.org/10.1080/23723556.2015.1035690

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