Serum C-Reactive Protein in chronic kidney disease patients undergoing hemodialysis and correlation with dialytic age

Abstract

Mortality in CKD patients undergoing hemodialysis considerably high. Previous study showed that mortality in patients undergoing hemodialysis was strongly correlated with chronic inflammation. The current study examined whether the serum c-reative protein concentration (hsCRP) changed from pre- to post-dialysis. In addition, the current study also investigated the correlation between dialysis age and hsCRP in chronic kidney disease patients undergoing hemodialysis. The study was a case-series study of 30 patients with hemodialysis. The patients were devided into three group based on dialysis age. Hemodialysis had been undergone for 4 hours, using hemoflow F8HPS, polysulfone synthetic dialysis membrane, and bicarbonate dialysis fluid. The primary outcome was serum concentration of high-sensitivity C-reactive protein (hsCRP), which was assessed in the pre-and-post dialysis, measured using chemiluminescent method. Dialysis does increased the hsCRP post-dialysis. It resulted in significant (p<0.05) increment of serum hsCRP concentration, pre-dialysis 1.04±0.90 mg/L compared to post-dialysis mean value 1.84±2.01 mg/dL. There was no significant difference among serum hsCRP concentration mean value among group of dialysis age. The correlations between various measurement of serum hsCRP concentration and dialysis age were statistically insignificant.