Abstract
Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered. © 2007 Elsevier Ltd. All rights reserved.
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Lincoln, S. J., Ross, O. A., Milkovic, N. M., Dickson, D. W., Rajput, A., Robinson, C. A., … Farrer, M. J. (2007). Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy. Parkinsonism and Related Disorders, 13(6), 340–342. https://doi.org/10.1016/j.parkreldis.2006.12.005
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