Development of calcium phosphate coatings with regulated porous structure as drug carrier systems

Abstract

The calcium phosphate coatings were formed by the micro-arc oxidation method under different applied voltage. It was shown that the thickness, surface roughness, porosity and sizes of the structural elements of the coatings increased with increasing of the applied voltage. In addition, the increase in the voltage led to the structural-phase transformation in the coatings from the amorphous state to the amorphous-crystalline state with incorporation of CaHPO4, α-Ca2P2O7, β-Ca2P2O7 and TiO2 (anatase) nano-sized phases. The micro-porous amorphous coatings formed at a low voltage of 200 V showed the highest adsorption of the doxorubicin. The formed coatings with regulated porous structure and specified phase composition can be used as anticancer (e.g., doxorubicin) drug carrier systems.