Hyponatraemic seizures resulting from inadequate post-operative fluid intake following a single dose of desmopressin

Abstract

In summary, our case highlights the importance of fluid restriction and regular checking of serum [Na+] when intravenous DDAVP is used, especially in children. Since even a single dose of he drug may induce symptomatic hyponatraemia within 12 h, serum [Na+] and urine output must be checked every 6 h for the first 24 h after administering DDAVP, as suggested by Sutor [8]. Taking this information ino account will help to prevent this serious adverse effect of DDAVP, and will provide additional safety and effectiveness in is clinical use. © The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.