Tio2 decorated low-molecular chitosan a microsized adsorbent for a68ge/68ga generator system

Abstract

We report column material for a68Ge/68Ga generator with acid resistance and excellent adsorption and desorption capacity of68Ge and68Ga, respectively. Despite being a core element of the68Ge/68Ga generator system, research on this has been insufficient. Therefore, we synthesized a low molecular chitosan-based TiO2 (LC-TiO2 ) adsorbent via a physical trapping method as a durable68Ge/68Ga generator column material. The adsorption/desorption studies exhibited a higher separation factor of68Ge/68Ga in the concentration range of HCl examined (0.01 M to 1.0 M). The prepared LC-TiO2 adsorbent showed acid resistance capabilities with >93% of68Ga elution yield and 1.6 × 10−4% of68Ge breakthrough. In particular, the labeling efficiency of DOTA and NOTA, by using the generator eluted68Ga, was quite encouraging and confirmed to be 99.65 and 99.69%, respectively. Accordingly, the resulting behavior of LC-TiO2 towards68Ge/68Ga adsorption/desorption capacity and stability with aqueous HCl exhibited a high potential for ion-exchange solid-phase extraction for the68Ge/68Ga generator column material.