SpotXplore: A Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks

Abstract

Summary: SpotXplore is a plugin for Cytoscape for extraction and visualization of differentially expressed subnetworks (hotspots) from gene networks. The hotspot-based visualization approach enables interactive exploration of regulatory interactions in differentially expressed gene sets, and it allows a researcher to explore gene expression in direct relation to the affected cellular gene network. The hotspots provide a view beyond the commonly used metabolic pathways and gene ontologies. © The Author(s) 2010. Published by Oxford University Press.