Maryland ACP Mulholland Mohler winning resident abstracts 2018

Abstract

Albendazole and oral ivermectin were initiated through a nasogastric tube, but given the intestinal ileus, absorption was questionable. [...]measures were taken to obtain a veterinary subcutaneous ivermectin formulation and a request was submitted to the Food and Drug Administration (FDA) for compassionate use. Discussion: Critically ill patients infected with strongyloides stercoralis can develop hyperinfection syndrome, which is dangerous and challenging to treat, especially if concomitant intestinal malabsorption is present. Since parenteral ivermectin is not approved in humans, an unorthodox approach may be needed with the use of a veterinary formulation of subcutaneous ivermectin, which will require FDA approval. [...]when dealing with a patient population at risk for strongyloides infection, it is prudent to have different formulations of antiparasitic agents readily available and seek early FDA approval for the use of veterinary preparations. 1st Place Poster Research Winner Mulholland Mohler Residents Meeting - Maryland Chapter 2018 - Dr. Amir Ansari, Medstar Health Internal Medicine, Baltimore, MD - Blockade of Sonic Hedgehog Signalling Pathway; A Novel Preventive Approach for Esophageal Adenocarcinoma Drs. Amir Ansari, Tomoharu Miyashita, Guy P. Marti, Ken-ichi Mukaisho, Elizabeth Montgomery, Michelle Rudek-Renaut PharmD, Christine Chung, Ronan Joseph Kelly, John W. Harmon, FACS, Johns Hopkins University School of Medicine, Baltimore MD Background: Up-regulated progenitor cell proliferation induced by abnormal activation of the Sonic Hedgehog (SHH) signalling pathway contributes to carcinogenesis in the esophagus and SHH is considered a leading candidate as a molecular mediator of Barrett's Esophagus. [...]subgroup analysis of LOS found that the reporting group had significantly lower hospital mortality if their LOS was between 6 and 10 days (73.4% vs 28.6%, p = 0.007).