K-13, a novel inhibitor of angiotensin i converting enzyme produced by micromonospora halophytica subsp. exilisia: II. Structure determination

Abstract

The structure of K-13, a potent inhibitor of angiotensin I converting enzyme (ACE), was determined to be a cyclic dipeptide composed of tyrosine and an unusual diamino dicarboxylic acid, isodityrosine, by spectral and chemical studies of K-13 and its derivatives. © 1987, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.