6-Gingerol and Shogaol; A Comprehensive Strategy Against Various Maladies

Abstract

Ginger is the oldest medical herb due to its therapeutic and prophylactic activities. These properties are associated with the presence of the gingerol and shogaol. The literature pertaining to current review article has been mainly emphasized on the therapeutic potential of ginger along with active bio-ingredients against cancer insurgence, diabetic &oxidative stress complications, obesity and cardiovascular discrepancies. It prevents from cancer insurgence through restraining the cancer stages such as initial, promotion and progression. Particularly, it also suppresses the lipid per-oxidation, nitric oxide synthetase activity, epidermal growth factor (EGF) receptor, protein kinase c, enzyme activity, survival signaling (NIK, IKK, and AKT), NF-κB activity, and cell cycle regulation. The current review article discusses the role of gingerol bioactive component against different type of cancers and its allied health perspectives.