Biochemical investigation of an experimentally induced metabolic syndrome in rats

Abstract

Metabolic syndrome (MS) is a complex condition characterized by insulin resistance, hyperglycemia, dyslipidemia, and obesity. This project aims to induce MS in rat and then a demonstration of the main biochemical parameters. In male, Sprague-Dawley rats, MS has been prompted suitably and relatively by fast (six weeks) approach through a high fructose in drinking water (40%). It has been found that serum urea, creatinine and total bilirubin raise in MS significantly. Moreover, dyslipidemia has arbitrated via some considerable lipid profile deviations. In addition, BMI, blood glucose, and insulin monitoring evidently ensure achievement of MS. It is concluded that a well-established rat model of MS could be employed by a 40% fructose in drinking water.