Studies in the chemical constituents of the seeds of Peganum Harmala: Isolation and structure elucidation of two β-carboline lactams - Harmalanine and harmalacidine

Abstract

Two β-carboline lactams harmalanine and harmalacidine have been isolated from the seeds of Peganum harmala and their structures were elucidated as I and II respectively through chemical and spectroscopic studies. In the case of I, which is the simplest tetracyclic β-carboline lactam from any source, detailed nmr (1H and 13C) investigations including nOe difference, 2D nmr (cosy-45, noesy, J-resolved) double resonance experiments and 1H-13C-hetero-COSY measurements have been used. © 1988.