A facile synthesis of 1,1-difluoroallenes from commercially available 1,1,1-trifluoro-2-iodoethane

Abstract

1,1-Difluoroallenes are synthesized in good yield via zinc-promoted 1,2-elimination of 3,3-difluoro-2-iodoallylic acetates, which are prepared by the reaction of aldehydes or ketones with 1-iodo-2,2-difluorovinyllithium, generated from commercially available 1,1,1-trifluoro-2-iodoethane. © Georg Thieme Verlag Stuttgart - New York.