SP358STUDYON CORRELATION BETWEEN SERUM CREATININE AND URINARY ALBUMIN CREATININE RATIO AND BODY COMPOSITION IN GENERAL POPULATION

Abstract

Introduction and Aims: In epidemiological studies, there is no study on the relationship between the human body composition and serum creatinine, urinary albumin creatinine ratio. Based on data from our epidemiological survey, to study the correlation between serum creatinine, Cystatin-C and urinary albumin creatinine ratio and body composition in general population. Methods: Residents over the age of 35 of the Beijing Pinggu District by stratified random sampling method, in the selected five towns of 42 villages, according to the household registration form per household using random table 1 were chosen at random were investigated. All participants signed informed consent. As a cross-sectional survey, questionnaire survey, physical examination and laboratory testing. Laboratory test: take morning urine albumin to creatinine ratio (ACR), blood samples were taken for blood routine, liver and kidney function, blood lipids. Before and after emptying the bladder using body composition of INBODY-720 type measuring instrument for measuring body composition. Survey data with EpiData 3.0 software double entry, using SPSS 17.0 software for data statistical analysis, count data using multivariate linear regression analysis. Results: A total of 9283 people participated in the survey, which 4324 males, age 54.7 ±10.7 years, 4959 females, age 53.4±11.2 years. Male: 1) Human body cell mass (BCM) and ACR, Cystatin-C, no correlation, was positively correlated with height (B=0.43, P<0.01), and serum creatinine was that positive correlation (B=.01, P<0.01) . 2) Lean body mass (FFM) and ACR, serum creatinine, Cystatin-C, no correlation. 3) Skeletal muscle content and ACR, serum creatinine, Cystatin-C, no correlation. 4) Body fat mass and ACR, no correlation, and Cystatin-C was positively correlated with (B=7.09, P < 0.01), and age is negative correlation (B=-0.065, P<0.01). Female: 1) Human body cell mass (BCM) with height and cystatin-C, no correlation , but positively correlated with serum creatinine (B=0.035, P<0.01), and ACR was negative correlation (B=-0.005, P<0.05). 2) Lean body mass (FFM) and ACR, Cystatin-C, no correlation, and serum creatinine were positively related (B=0.035, P<0.01). 3) Skeletal muscle content and ACR, Cystatin-C, no correlation, and was positively correlated with height (B=0.031, P<0.01), and serum creatinine were positively related (B=0.035, P<0.01). 4) Body fat mass and ACR was negative correlation (B=-0.01, P<0.05), Cystatin-C were positively correlated (B=12.3, P<0.01), and age were negatively correlated (B=-0.13, P<0.01), and serum creatinine was negative correlation (B=-0.092, P<0.01). Conclusions: ACR were no clear correlation with body cell mass (BCM), lean body mass (FFM), skeletal muscle mass or body fat. There was a positive correlation between serum creatinine and the human body cell mass (BCM), lean body mass (FFM) in men, and skeletal muscle content, body fat weight in women, but the correlation is not strong. The blood cystatin-C and body fat weight was positively correlated.