Chemoselective amide ligations by decarboxylative condensations of N-alkylhydroxylamines and α-ketoacids

Abstract

(Chemical Equation Presented) Additive-free: The chemoselective amide-bond-forming ligation between N-alkylhydroxylamines and α-ketoacids requires no reagents and the only by-products are water and carbon dioxide. This process proceeds on unprotected peptide substrates without epimerization, and as such, this process has the potential to serve as a novel chemoselective ligation for the synthesis of peptides and complex materials. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.